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Immune checkpoint dysfunction in large and medium vessel vasculitis

Simultaneous injection of glucose and insulin can transiently overcome deficit, administration of exogenous BHB can overcome the deficit by bypassing and going straight through alpha-hydroxybutyrate into the Krebs cycle

The LC/MS portion of the platform was based on a Surveyor HPLC and a Thermo-Finnigan LTQ Fmass spectrometer (Thermo scientific, Waltham, Massachusettes, USA), which consisted of an electrospray ionization (ESI) source and linear ion-trap (LIT) mass analyzer

The fusion loops of the initial prefusion conformation of herpes simplex virus 1 fusion protein point toward the membrane